For discussion, I choose the “spiritual molecule” DMT (N, N-Dimethyltryptamine). In the Amazon, tribes create a brew called the ayahuasca known “hundreds of years old,” while more recently a man found the correlations of animals agitating toads to form secretions, but not killing them and was the first man to have smoked the secretion and first man to have “licked the toad.”

There is an impressive documentary on vice about this man. While DMT is found in nature in a large variety of organisms such as animals, plants, fungi, and amphibians just to name a few, this may make you wonder, what is DMT?


The foundation of DMT’s structure is the Indole (C₈H₇N), a molecule consisting of a benzene ring fused to a pyrrole. This aromatic heterocyclic compound a “bicyclic cycle.”

The indole forms a tryptamine (monoamine alkaloid) when the indole’s pyrrole is attached to an ethylamine group. The substituted groups (R1) connected from the amine are known as a substituted tryptamine (serotonin analogs).

In DMT the substituted tryptamine consists of two methyl groups attached to the amine atom (hence N, N-di prefix).


In experimental properties, DMT is a solid, crystal with boiling points of 60 to 80 degrees C and melting points of 46 °C. The image above illustrates MEP surface at different positions.

It’s pharmaceutical properties consist of mainly hallucinogenic properties, causing psychedelic experiences among users. In society, the Amazon tribes create brews that contained DMT. The type of DMT is still highly debated. The debate consists of identification of the first chemist who isolated DMT, and that first structured isolated form of DMT. In the Amazon brews, this type of DMT is occurring in the naturing sate. In other samples of the DMT psychedelics, the kind of DMT differs.

MeO-DMT (5-methoxy-N, N-dimethyltryptamine) is one of those analogs. MeO-DMT was isolated from the ingredients of the Anadenanthera peregrina seeds used to produce Yopo snuff. 5-MeO-DMT is also the psychedelic drug found in the toad species.

Chemically, this analog contains a hydroxy group on the benzene ring. And with tryptamine as the backbone, it’s not hard to imagine the other types of analogs found in nature.